In 2000, the long deserted Fix brewery, a remarkable industrial building in the centre of Athens, created by the architect Takis Zenetos, is selected as the permanent house of the newly founded EMST, with the perspective to be reconstructed and thus serve the edificial and functional demands of the Museum. 

Despite the demolition of one part, the building offered significant unified spaces of a total of 20,000 square meters and of a total volume of 90,000 cubic meters which allowed the gathering of the Museum's main functions, such as permanent and periodical exhibitions, administration, archives, library, an auditorium, laboratories, an art-store, cafeteria and restaurant e.a.   Its position was considered as a unique advantage, as it is placed at a short distance from the historic and commercial centre of Athens and the New Acropolis Museum and thus attracts a significant number of Greek and foreign visitors, and favours the creation of a grand promenade where classic antiquity meets contemporary art.

Furthermore, the possibility of its immediate accessibility with the operation of the Metro line station on the Building's field, the Transit Station and the Trolley - Train network, which passes by Kallirrois Avenue, constituted unique advantages in the sense of transportation services, in the wider area of the capital.